Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.

@article{Csanaky2009RoleOH,
  title={Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.},
  author={Iv{\'a}n L. Csanaky and Lauren M. Aleksunes and Yuji Tanaka and Curtis D. Klaassen},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={297 3},
  pages={G419-33}
}
The enterohepatic recirculation of bile acids (BAs) is important in several physiological processes. Although there has been considerable research on liver regeneration after two-thirds partial hepatectomy (PHx), little is known about how the liver protects itself against BA toxicity during regeneration. In this study, various BAs in plasma and liver, the composition of micelle-forming bile constituents, as well as gene expression of the main hepatobiliary transporters were quantified in sham… CONTINUE READING

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