Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

@article{Shafi1994RoleOH,
  title={Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.},
  author={Shahida Shafi and S E Brady and Andr{\'e} Bensadoun and Richard J. Havel},
  journal={Journal of lipid research},
  year={1994},
  volume={35 4},
  pages={
          709-20
        }
}
The participation of hepatic lipase in the initial uptake and processing of chylomicron remnants was studied in the isolated, perfused rat liver. Hepatic lipase activity was either reduced by preperfusion of livers with heparin or inhibited with specific rat hepatic lipase antibodies. [3H]palmitate-labeled chylomicron remnants were recirculated through control and treated livers for 15 min; the livers were then flushed, homogenized, and endosome-rich fractions were isolated. Depletion of… CONTINUE READING

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