Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection.

@article{Foresti2001RoleOH,
  title={Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection.},
  author={R. Foresti and H Goatly and Colin J. Green and Roberto Motterlini},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={281 5},
  pages={H1976-84}
}
Heme oxygenase-1 (HO-1) catalyzes the enzymatic degradation of heme to carbon monoxide, bilirubin, and iron. All three products possess biological functions; bilirubin, in particular, is a potent free radical scavenger of which its antioxidant property is enhanced at low oxygen tension. Here, we investigated the effect of severe hypoxia and reoxygenation on HO-1 expression in cardiomyocytes and determined whether HO-1 and its product, bilirubin, have a protective role against reoxygenation… CONTINUE READING
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