Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants.

  title={Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants.},
  author={Hevidar Taha and Klaudia Skrzypek and Ibeth Guevara and Anneliese Nigisch and Stefan Mustafa and Anna Grochot-Przęczek and Pawel Ferdek and Halina Waś and Jerzy Kotlinowski and Magdalena Kozakowska and Aneta Balcerczyk and Lucie Muchov{\'a} and Libor V{\'i}tek and Guenter Weigel and Jozef Dulak and Alicja Jozkowicz},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={30 8},
OBJECTIVE Heme oxygenase-1 (HO-1) is an antioxidative, antiinflammatory, and cytoprotective enzyme that is induced in response to cellular stress. The HO-1 promoter contains a (GT)n microsatellite DNA, and the number of GT repeats can influence the occurrence of cardiovascular diseases. We elucidated the effect of this polymorphism on endothelial cells isolated from newborns of different genotypes. METHODS AND RESULTS On the basis of HO-1 expression, we classified the HO-1 promoter alleles… CONTINUE READING
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HIF-1 induction attenuates Nrf2-dependent IL-8 production in human endothelial cells

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