Role of heme oxygenase-1 in demethylating effects on SKM-1 cells induced by decitabine.

Abstract

We evaluated the influence of heme oxygenase-1 (HO-1) gene inhibition in myelodysplastic syndrome (MDS) cell line SKM-1 on enhancement of the demethylating effects of decitabine on p15, and explored the possible mechanism. DNMT1 gene expression in SKM-1 cells was silenced by being transfected by a constructed siRNA with liposomes. The proliferation… (More)
DOI: 10.4238/2015.December.22.3

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@article{Gao2015RoleOH, title={Role of heme oxygenase-1 in demethylating effects on SKM-1 cells induced by decitabine.}, author={Run Lin Gao and D Ma and P. Wang and J. Sun and Jia-sheng Wang and Qiuwen Fang}, journal={Genetics and molecular research : GMR}, year={2015}, volume={14 4}, pages={17788-98} }