Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine.

Abstract

Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with analyses of mutants were performed in an effort to elucidate its… (More)

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@article{Agarwal2008RoleOH, title={Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine.}, author={Ameeta Kishore Agarwal and Tao Xu and Melissa Ruth Jacob and Qin Feng and Michael C Lorenz and Larry A Walker and Alice Mae Clark}, journal={Eukaryotic cell}, year={2008}, volume={7 2}, pages={387-400} }