Role of helix 0 of the N-BAR domain in membrane curvature generation.

@article{Fernandes2008RoleOH,
  title={Role of helix 0 of the N-BAR domain in membrane curvature generation.},
  author={F{\'a}bio Fernandes and Lu{\'i}s M. S. Loura and Francisco J Chich{\'o}n and Jos{\'e} L Carrascosa and Alexander E Fedorov and Manuel Prieto},
  journal={Biophysical journal},
  year={2008},
  volume={94 8},
  pages={3065-73}
}
A group of proteins with cell membrane remodeling properties is also able to change dramatically the morphology of liposomes in vitro, frequently inducing tubulation. For a number of these proteins, the mechanism by which this effect is exerted has been proposed to be the embedding of amphipathic helices into the lipid bilayer. For proteins presenting BAR domains, removal of an N-terminal amphipathic alpha-helix (H0-NBAR) results in much lower membrane tubulation efficiency, pointing to a… CONTINUE READING

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