Role of hedgehog signaling in ovarian cancer.

  title={Role of hedgehog signaling in ovarian cancer.},
  author={Resham Bhattacharya and Junhye Kwon and Bushra Tariq Ali and Enfeng Wang and Sujata Patra and Viji Shridhar and Priyabrata Mukherjee},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={14 23},
PURPOSE In humans, several distinctive cancers result from mutations that aberrantly activate hedgehog (HH) signal transduction. Here, we investigate the role of HH signaling in ovarian cancer. EXPERIMENTAL DESIGN We assessed the expression of different components of hedghehog pathway in primary tumor samples and cell lines. We used specific hedghehog pathway blocker to study the effect on clonal growth and proliferation of ovarian cancer cell both in vitro and in vivo. RESULTS We show that… CONTINUE READING
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