Role of gut in xenobiotic metabolism

  title={Role of gut in xenobiotic metabolism},
  author={Osmo H{\"a}nninen and Pirjo Lindstr{\"o}m-Sepp{\"a} and Kai H O Pelkonen},
  journal={Archives of Toxicology},
The gastrointestinal tract forms the first line of defense in the body against the main load of xenobiotics. The gastrointestinal mucosa has several mechanisms through which the xenobiotics are modified. The monooxygenase activities in most species are relatively low in the mucosa as compared to the liver, but conjugation, for example, via glucuronide formation proceeds efficiently. UDP-glucuronosyltransferase activities can exceed those in the liver. Glutathione S-transferase activity is also… CONTINUE READING


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