Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity.

@article{Yamamoto2004RoleOG,
  title={Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity.},
  author={Masafumi Yamamoto and M S Kweon and Paul D. Rennert and Takachika Hiroi and Kohtaro Fujihashi and Jerry R. Mcghee and Hiroshi Kiyono},
  journal={Journal of immunology},
  year={2004},
  volume={173 2},
  pages={762-9}
}
This study assessed the roles of the postnatal lymphotoxin-beta receptor (LTbetaR)-mediated signals in the gut-associated lymphoreticular tissues of mice for subsequent regulation of Ag-specific intestinal IgA responses. Blockade of LTbetaR-dependent events by postnatal administration of the fusion protein of LTbetaR and IgG Fc (LTbetaR-Ig) reduced both the size and numbers of Peyer's patches (PP) without influencing the PP microarchitecture. Interestingly, inhibition of LTbetaR-dependent… CONTINUE READING
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