Role of guinea pig and rabbit hepatic aldehyde oxidase in oxidative in vitro metabolism of cinchona antimalarials.

@article{Beedham1992RoleOG,
  title={Role of guinea pig and rabbit hepatic aldehyde oxidase in oxidative in vitro metabolism of cinchona antimalarials.},
  author={Christine Beedham and Y. Al-Tayib and Jayden A. Smith},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1992},
  volume={20 6},
  pages={889-95}
}
Cinchona alkaloids (quinine, quinidine, cinchonine, and cinchonidine) were incubated with partially purified aldehyde oxidase from rabbit or guinea pig liver. Reversed-phase HPLC methods were developed to separate the oxidation products from the parent drugs, and the metabolites were identified on the basis of their infrared and mass spectral characteristics. All four alkaloids were oxidized at carbon 2 of the quinoline ring to give the corresponding lactams. In addition, the dihydro… CONTINUE READING

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