Role of guanine nucleotides as endogenous ligands of a kainic acid binding site population in the mammalian cerebellum.

@article{Migani1997RoleOG,
  title={Role of guanine nucleotides as endogenous ligands of a kainic acid binding site population in the mammalian cerebellum.},
  author={Paolo Migani and Rosamaria Fiorini and Enrica Ferretti and Elena Manini and Stefano Chimichi and Gloriano Moneti},
  journal={Journal of neurochemistry},
  year={1997},
  volume={68 4},
  pages={1648-54}
}
An endogenous inhibitor of the membrane binding of kainic acid was extracted from pig brain tissue and purified. The substance was identified as GMP by structural analysis: Most likely it corresponds to an inhibitor previously extracted from the rat brain. The nucleotide is active as an inhibitor for kainate binding on goldfish brain synaptosomes, probably owing to direct displacement on receptor sites; it is also active on a low-affinity kainate site population in membranes from rat cerebellum… CONTINUE READING

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