Role of growth factors and cytokines in hepatic regeneration

@article{Fausto1995RoleOG,
  title={Role of growth factors and cytokines in hepatic regeneration},
  author={Nelson Fausto and A D Laird and Eric M. Webber},
  journal={The FASEB Journal},
  year={1995},
  volume={9},
  pages={1527 - 1536}
}
During liver regeneration quiescent hepatocytes undergo one or two rounds of replication and then return to a nonproliferative state. Growth factors regulate this process by providing both stimulatory and inhibitory signals for cell proliferation. EGF, TGFα, and HGF stimidate DNA synthesis in hepatocytes in vivo and in culture but the sensitivity of cidtured hepatocytes to the mitogenic effects of these factors is much higher than that of quiescent hepatocytes in intact livers. We have proposed… Expand
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