Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats.

@article{Murakami1997RoleOG,
  title={Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats.},
  author={Kazushi Murakami and Kenji Okajima and Mitsuhiro Uchiba and Naoaki Harada and Wenge Liu and Hiroaki Okabe and Kiyoshi Takatsuki},
  journal={The Journal of laboratory and clinical medicine},
  year={1997},
  volume={130 3},
  pages={307-13}
}
To investigate whether granulocyte elastase may be involved in indomethacin-induced gastric mucosal injury, we examined the effects of the granulocyte elastase inhibitors ONO-5046 and L-658,758 on gastric mucosal lesion formation in rats given indomethacin. Both gastric mucosal lesion formation and gastric mucosal vascular damage were markedly attenuated in animals with leukocytopenia and in those given granulocyte elastase inhibitors. The administration of indomethacin significantly increased… CONTINUE READING

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