Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects.

Abstract

IL-6-type cytokines bind to plasma membrane receptor complexes containing the common signal transducing receptor chain gp130 that is ubiquitously expressed in most tissues including the heart. The two major signalling cascades activated by the gp130 receptor, SHP2/ERK and STAT pathways, have been demonstrated to play important roles in cardiac development… (More)
DOI: 10.1038/bjp.2008.1

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