Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer

  title={Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer},
  author={Carsten Gruendker and Guenter Emons},
  journal={Reproductive biology and endocrinology : RB&E},
  pages={65 - 65}
The expression of GnRH (GnRH-I, LHRH) and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the ovary. The proliferation of human ovarian cancer cell lines is time- and dose-dependently reduced by GnRH and its superagonistic analogs. The classical GnRH receptor signal-transduction mechanisms, known to operate in the pituitary, are not involved in the mediation of antiproliferative… CONTINUE READING


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A novel mammalian receptor for the evolutionarily conserved type II GnRH.

Proceedings of the National Academy of Sciences of the United States of America • 2001
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Biology of the GnRH system in human gynecological cancers

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