Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.

@article{Vilches1992RoleOG,
  title={Role of glycosylation and deglycosylation in biosynthesis of and resistance to oleandomycin in the producer organism, Streptomyces antibioticus.},
  author={Carmen Vilches and C{\'e}sar Hern{\'a}ndez and Cioly M{\'e}ndez and Jos{\'e} A Salas},
  journal={Journal of bacteriology},
  year={1992},
  volume={174 1},
  pages={161-5}
}
Cell extracts of Streptomyces antibioticus, an oleandomycin producer, can inactivate oleandomycin in the presence of UDP-glucose. The inactivation can be detected through the loss of biological activity or by alteration in the chromatographic mobility of the antibiotic. This enzyme activity also inactivates other macrolides (rosaramicin, methymycin, and lankamycin) which contain a free 2'-OH group in a monosaccharide linked to the lactone ring (with the exception of erythromycin), but not those… CONTINUE READING
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Antibiotic tolerance in producer organisms

  • B. Weisblum
  • Adv . Appl . Microbiol .
  • 1979

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