Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils.

@article{Ren2010RoleOG,
  title={Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils.},
  author={Ruiyi Ren and Zhenning Hong and Haiyan Gong and K. de Laporte and Martha Skinner and David C. Seldin and Catherine E. Costello and Lawreen H Connors and Vickery E Trinkaus-Randall},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 48},
  pages={37672-82}
}
Primary amyloidosis (AL) results from overproduction of unstable monoclonal immunoglobulin light chains (LCs) and the deposition of insoluble fibrils in tissues, leading to fatal organ disease. Glycosaminoglycans (GAGs) are associated with AL fibrils and have been successfully targeted in the treatment of other forms of amyloidosis. We investigated the role of GAGs in LC fibrillogenesis. Ex vivo tissue amyloid fibrils were extracted and examined for structure and associated GAGs. The GAGs were… CONTINUE READING
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Role of GAGs in AL Fibrils 37682 JOURNAL OF BIOLOGICAL CHEMISTRY

  • E. Elimova, R. Kisilevsky, J. B. andAncsin
  • FASEB J. 23,
  • 2009

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