Role of glycolysis and antioxidant enzymes in the toxicity of amyloid beta peptide Aβ25–35 to erythrocytes

@article{Kosenko2008RoleOG,
  title={Role of glycolysis and antioxidant enzymes in the toxicity of amyloid beta peptide Aβ25–35 to erythrocytes},
  author={Elena A Kosenko and Ilya N Solomadin and Nikolay Marov and Natalya I Venediktova and Anush Poghosyan and Yu. G. Kaminsky},
  journal={Russian Journal of Bioorganic Chemistry},
  year={2008},
  volume={34},
  pages={586-592}
}
The role of glycolysis and antioxidant enzymes in amyloid beta peptide Aβ25–35 toxicity to human and rat erythrocytes was studied. The erythrotoxicity of Aβ25–35 was shown to increase two-to fourfold both in the absence of glucose in the incubation medium and upon the addition of sodium fluoride, an enolase inhibitor. Potassium cyanide, a Cu,Zn-superoxide dismutase inhibitor, abolishes the toxic effect of Aβ25–35 to erythrocytes, whereas mercaptosuccinate, a glutathione peroxidase inhibitor… CONTINUE READING

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