Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

@article{Domnguez1995RoleOG,
  title={Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.},
  author={Isabel Dom{\'i}nguez and Keiji Itoh and Sergei Y Sokol},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 18},
  pages={8498-502}
}
The dorsoventral axis is established early in Xenopus development and may involve signaling by Wnts, a family of Wnt1-protooncogene-related proteins. The protein kinase shaggy functions in the wingless/Wnt signaling pathway, which operates during Drosophila development. To assess the role of a closely related kinase, glycogen synthase kinase 3 beta (GSK-3 beta), in vertebrate embryogenesis, we cloned a cDNA encoding a Xenopus homolog of GSK-3 beta (XGSK-3 beta). XGSK-3 beta-specific transcripts… CONTINUE READING
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