Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide.

@article{Gurtoo1981RoleOG,
  title={Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide.},
  author={Hira L. Gurtoo and J H Hipkens and Shubh D. Sharma},
  journal={Cancer research},
  year={1981},
  volume={41 9 Pt 1},
  pages={3584-91}
}
The role of glutathione in the biological effects of cyclophosphamide (CP) was evaluated by investigating the following: effect of CP on hepatic glutathione levels; relationship between hepatic glutathione depletion (repletion) and the binding of [chloroethyl-3H]CP and [4-14C]CP to hepatic macromolecules; effects of interaction between CP (or acrolein) and diethyl maleate (a classical glutathione depletor), and/or between CP and cysteine on the binding of labeled CP to hepatic macromolecules… CONTINUE READING

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Protection by A/-acetylcysteine of cyclophosphamide metabolism-re lated in vivo depression of mixed function oxygenase activity and in vitro denaturation of cytochrome P-450

  • M. J. Berrigan, Gurtoo, L H., S. D. Sharma, R. F. Struck, A. J. Mannello
  • Biochem. Biophys. Res. Commun.,
  • 1980
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