Role of glutathione in reproductive tract secretions on mouse preimplantation embryo development.

@article{Salmen2005RoleOG,
  title={Role of glutathione in reproductive tract secretions on mouse preimplantation embryo development.},
  author={James J Salmen and Frank Skufca and Ani Matt and Gene Gushansky and Amy G Mason and Catherine S. Gardiner},
  journal={Biology of reproduction},
  year={2005},
  volume={73 2},
  pages={308-14}
}
We investigated the hypothesis that glutathione (GSH) in reproductive tract secretions (RTS) protects the preimplantation embryo from endogenous reactive oxygen species and is important for normal development during the embryo's sensitive period when it is incapable of synthesizing GSH de novo. Mice were administered buthionine sulfoximine (BSO) to inhibit GSH synthesis and decrease GSH concentration in RTS. Embryos were then allowed to develop either in vivo or in vitro in the presence of RTS… CONTINUE READING
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