Role of glutathione in protection against noise-induced hearing loss

@article{Yamasoba1998RoleOG,
  title={Role of glutathione in protection against noise-induced hearing loss},
  author={Tatsuya Yamasoba and Alfred L. Nuttall and Craig Harris and Yehoash Raphael and Josef M. Miller},
  journal={Brain Research},
  year={1998},
  volume={784},
  pages={82-90}
}
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176 Citations
Highly Influential Citations
4
Background Citations
55
Methods Citations
2
Results Citations
2

176 Citations

Glutathione limits noise-induced hearing loss

Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea

Effects of α-tocopherol on noise-induced hearing loss in guinea pigs

Influence of intense sound exposure on glutathione synthesis in the cochlea

Oxidative stress pathways in the potentiation of noise-induced hearing loss by acrylonitrile

Dose and time-dependent protection of the antioxidant N-l-acetylcysteine against impulse noise trauma

Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea

Oxidative DNA damage is associated with intense noise exposure in the rat

Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo

Influence of noise exposure on antioxidant system and TEOAEs in rabbits

TLDR
Findings indicate that TEOAE recording is an excellent test for detecting effects of noise on hearing and there is a close relationship between noise-induced hearing loss and the antioxidant system.
...

References

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TLDR
Findings show that SOD-PEG and allopurinol may preserve cochlear sensitivity associated with noise exposure, which suggests that noise-induced damage to the cochlea may be related to the activity of FORs.

Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function

Glutathione protection against gentamicin ototoxicity depends on nutritional status

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TLDR
Findings may explain the clinical observations of enhanced ototoxicity in patients administered aminoglycoside antibiotics concomitantly with loop diuretics and determine cochlear and renal vulnerability to this toxicity.

Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo

Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants

The Protective Effects of Allopurinol and Superoxide Dismutase-Polyethylene Glycol on Ischemic and Reperfusion-Induced Cochlear Damage

TLDR
Results indicate that damage to the cochlea from ischemia and subsequent reperfusion can be attenuated by pretreatment with allopurinol or SOD-PEG, indirect evidence that FORs may be partially responsible for cochlear damage resulting from ischemic conditions.

Direct effects of reactive oxygen species on cochlear outer hair cell shape in vitro

Diet is a risk factor in cisplatin ototoxicity

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TLDR
Results indicate that oxidative stress due to loss of cellular levels of GSH is one mechanism whereby Glu/quisqualate exert cytotoxicity and suggest that centrally active antioxidants may reduce neuronal damage in pathologic conditions associated with excessive Glu release.
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