Role of glutathione in protection against noise-induced hearing loss

@article{Yamasoba1998RoleOG,
  title={Role of glutathione in protection against noise-induced hearing loss},
  author={Tatsuya Yamasoba and Alfred L. Nuttall and Craig Harris and Yehoash Raphael and Josef M. Miller},
  journal={Brain Research},
  year={1998},
  volume={784},
  pages={82-90}
}
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174 Citations
Highly Influential Citations
3
Background Citations
54
Methods Citations
2
Results Citations
1

174 Citations

Protective effects of N-acetylcysteine on noise-induced hearing loss in guinea pigs.
TLDR
The data suggest that N-acetylcysteine is able to attenuate the toxic effect of acoustic trauma and could represent an interesting molecule for preventing inner ear injuries.
Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea
Effects of α-tocopherol on noise-induced hearing loss in guinea pigs
Influence of intense sound exposure on glutathione synthesis in the cochlea
Dose and time-dependent protection of the antioxidant N-l-acetylcysteine against impulse noise trauma
Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea
Oxidative DNA damage is associated with intense noise exposure in the rat
Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo
Influence of noise exposure on antioxidant system and TEOAEs in rabbits
TLDR
Findings indicate that TEOAE recording is an excellent test for detecting effects of noise on hearing and there is a close relationship between noise-induced hearing loss and the antioxidant system.
Protective effects of N-acetylcysteine on noise- induced hearing loss in guinea pigs Effetti protettivi della N-acetilcisteina nel modello animale dell'ipoacusia da rumore
TLDR
The data suggest that N-acetylcysteine is able to attenuate the toxic effect of acoustic trauma and could represent an interesting molecule for preventing inner ear injuries.
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References

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TLDR
Findings show that SOD-PEG and allopurinol may preserve cochlear sensitivity associated with noise exposure, which suggests that noise-induced damage to the cochlea may be related to the activity of FORs.
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Glutathione protection against gentamicin ototoxicity depends on nutritional status
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TLDR
Findings may explain the clinical observations of enhanced ototoxicity in patients administered aminoglycoside antibiotics concomitantly with loop diuretics and determine cochlear and renal vulnerability to this toxicity.
Attenuation of gentamicin ototoxicity by glutathione in the guinea pig in vivo
Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants
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TLDR
Results indicate that U74006F lessens cochlear damage occurring as a result of ischemia/reperfusion and supports the hypothesis that FOR-induced lipid peroxidation may be partly responsible for the cochlea damage that occurs from ischemIA.
The Protective Effects of Allopurinol and Superoxide Dismutase-Polyethylene Glycol on Ischemic and Reperfusion-Induced Cochlear Damage
TLDR
Results indicate that damage to the cochlea from ischemia and subsequent reperfusion can be attenuated by pretreatment with allopurinol or SOD-PEG, indirect evidence that FORs may be partially responsible for cochlear damage resulting from ischemic conditions.
Direct effects of reactive oxygen species on cochlear outer hair cell shape in vitro
Noise-induced cochlear hypoxia is intensity dependent, correlates with hearing loss and precedes reduction of cochlear blood flow.
TLDR
Hearing loss and cochlear hypoxia precede reduction in CoBF due to noise exposure and the potential mechanisms underlying these effects are discussed.
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