Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line

Abstract

The primary objective of this study was to determine the sequence of biochemical signaling events that occur after modulation of the cellular redox state in the B cell lymphoma line, PW, with emphasis on the role of mitochondrial signaling. L-Buthionine sulphoximine (BSO), which inhibits gamma glutamyl cysteine synthetase (γGCS), was used to modulate the… (More)
DOI: 10.1038/sj.cdd.4400959

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