Role of glutamate transporters in corticostriatal synaptic transmission.

  title={Role of glutamate transporters in corticostriatal synaptic transmission.},
  author={Corinne Beurrier and Gilles Bonvento and Lydia Kerkerian-Le Goff and Paolo Gubellini},
  volume={158 4},
High-affinity glutamate transporters (GTs) play a major role in controlling the extracellular level of this excitatory neurotransmitter in the CNS. Here we have characterized, by means of in vitro patch-clamp recordings from medium spiny neurons (MSNs), the role of GTs in regulating corticostriatal glutamatergic synaptic transmission in the adult rat. Charge transfer and decay-time, but not amplitude, of excitatory postsynaptic currents (EPSCs) were enhanced by dl-threo-beta-benzyloxyaspartate… CONTINUE READING