Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter.

Abstract

Human multidrug and toxic compound extrusion 1 (hMATE1) is an electroneutral H(+)/organic cation exchanger responsible for the final excretion step of structurally unrelated toxic organic cations in kidney and liver. To elucidate the molecular basis of the substrate recognition by hMATE1, we substituted the glutamate residues Glu273, Glu278, Glu300, and… (More)
DOI: 10.1152/ajpcell.00504.2007

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Cite this paper

@article{Matsumoto2008RoleOG, title={Role of glutamate residues in substrate recognition by human MATE1 polyspecific H+/organic cation exporter.}, author={Takuya Matsumoto and Takuji Kanamoto and Masato Otsuka and Hiroshi Omote and Yoshinori Moriyama}, journal={American journal of physiology. Cell physiology}, year={2008}, volume={294 4}, pages={C1074-8} }