Role of glutamate receptors in tetrabrominated diphenyl ether (BDE-47) neurotoxicity in mouse cerebellar granule neurons.

@article{Costa2016RoleOG,
  title={Role of glutamate receptors in tetrabrominated diphenyl ether (BDE-47) neurotoxicity in mouse cerebellar granule neurons.},
  author={Lucio Guido Costa and Sara Tagliaferri and Pamela J. Roqu{\`e} and Claudia Pellacani},
  journal={Toxicology letters},
  year={2016},
  volume={241},
  pages={159-66}
}
The polybrominated diphenyl ether (PBDE) flame retardants are developmental neurotoxicants, as evidenced by numerous in vitro, animal and human studies. PBDEs can alter the homeostasis of thyroid hormone and directly interact with brain cells. Induction of oxidative stress, leading to DNA damage and apoptotic cell death is a prominent mechanism of PBDE neurotoxicity, though other mechanisms have also been suggested. In the present study we investigated the potential role played by glutamate… CONTINUE READING
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