Role of glutamate ionotropic receptors in the dorsomedial hypothalamic nucleus on anxiety and locomotor behavior.

@article{Jardim2004RoleOG,
  title={Role of glutamate ionotropic receptors in the dorsomedial hypothalamic nucleus on anxiety and locomotor behavior.},
  author={Maria Carmen de Ara{\'u}jo M. Jardim and Francisco S Guimar{\~a}es},
  journal={Pharmacology, biochemistry, and behavior},
  year={2004},
  volume={79 3},
  pages={541-6}
}
The medial hypothalamus is proposed to play an important role in the modulation of defensive responses. Administration of a NMDA receptor antagonist (AP7) into the dorsomedial hypothalamic nucleus (DMH) of rats reduced exploratory behavior in the open field and elevated plus-maze (EPM), but failed to produce anxiolytic effects in the latter test. The objectives of the present work were to test the hypotheses that (i) AP7 injections into the DMH would also fail to induce anxiolytic effects in… CONTINUE READING
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