Role of glucose in interleukin-1 beta production by lipopolysaccharide-activated human monocytes.

@article{Orlinska1993RoleOG,
  title={Role of glucose in interleukin-1 beta production by lipopolysaccharide-activated human monocytes.},
  author={Urszula Orlinska and Robert C. Newton},
  journal={Journal of cellular physiology},
  year={1993},
  volume={157 1},
  pages={201-8}
}
When monocytes are activated with endotoxin (lipopolysaccharide [LPS]), they make and release several mediators, including interleukin-1 beta (IL-1 beta). This study was undertaken to investigate the role of glucose in IL-1 beta production by these cells. IL-1 beta was produced in a dose-dependent manner to glucose concentration in the culture medium. The uptake of (3H)2-deoxyglucose in monocytes was stimulated by LPS 1,554% after 10 minutes, 6,095% after 2 hours, then gradually declined after… CONTINUE READING

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