Role of glucokinase and glucose-6 phosphatase in the nutritional regulation of endogenous glucose production.


Two specific enzymes, glucokinase (GK) and glucose-6 phosphatase (Glc6Pase) enable the liver to play a crucial role in glucose homeostasis. The activity of Glc6Pase, which enables the liver to produce glucose, is increased during short-term fasting, in agreement with the enhancement of liver gluconeogenesis. During long-term fasting, Glc6Pase activity is… (More)


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