Role of glucocorticoids in ethanol-induced decreases in expression of MHC class II molecules on B cells and selective decreases in spleen cell number.

@article{Weiss1996RoleOG,
  title={Role of glucocorticoids in ethanol-induced decreases in expression of MHC class II molecules on B cells and selective decreases in spleen cell number.},
  author={Peter A. M. Weiss and Simon Collier and Stephen B Pruett},
  journal={Toxicology and applied pharmacology},
  year={1996},
  volume={139 1},
  pages={
          153-62
        }
}
Glucocorticoids have been implicated in some of the immunosuppressive effects associated with acute ethanol (EtOH) intoxication, but other neuroendocrine mediators that are induced by EtOH can also be immunosuppressive. The possibility that glucocorticoids may act additively or synergistically with other mediators to produce immunosuppression has not been fully investigated. In the present study, complementary methods were used to address this issue. EtOH dose-responsively decreased the… CONTINUE READING
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