Role of glucocorticoid hormones in arginine vasopressin gene regulation.

  title={Role of glucocorticoid hormones in arginine vasopressin gene regulation.},
  author={Jinyoung Kim and Sandra N. Summer and William M. Wood and Robert Schrier},
  journal={Biochemical and biophysical research communications},
  volume={289 5},
The mechanism underlying increased AVP synthesis and release in glucocorticoid deficiency is not known. Therefore, the present study was undertaken to investigate whether the mechanism was at the level of AVP gene transcription. The AVP gene promoter contains a consensus GRE, a CRE, and four AP2 sites. To assess the functional importance of these sites, 5' deletions of the AVP promoter were created and transient transfections were performed. Promoter activity in hypothalamic cells transfected… CONTINUE READING

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Regulation of vasopressin gene expression by cAMP and glucocorticoids in parvocellular neurons of the paraventricular nucleus in rat hypothalamic organotypic cultures.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003
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