• DOI:10.1038/OBY.2002.106
• Corpus ID: 11888887

Role of ghrelin polymorphisms in obesity based on three different studies.

@article{Ukkola2002RoleOG,
  title={Role of ghrelin polymorphisms in obesity based on three different studies.},
  author={Olavi H. Ukkola and Eric Ravussin and Peter Jacobson and Louis P{\'e}russe and Tuomo Rankinen and Matthias H. Tsch{\"o}p and Mark Louis Heiman and Arthur S. Leon and D. C. Rao and James S. Skinner and Jack H. Wilmore and Lars Sj{\"o}str{\"o}m and Claude Bouchard},
  journal={Obesity research},
  year={2002},
  volume={10 8},
  pages={
          782-91
        }
}

• O. Ukkola, E. Ravussin, +10 authors C. Bouchard
• Published 1 August 2002
• Medicine
• Obesity research

OBJECTIVE
Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study.

RESEARCH METHODS AND PROCEDURES
Body mass index (BMI), fat mass (FM) from underwater weighing, and abdominal fat from computerized tomography were measured. The ghrelin polymorphisms were identified by polymerase chain reaction.

RESULTS
Arg51Gln QFS subjects (n = 6) had lower ghrelin concentrations (p = 0.007) than Arg51Arg subjects (n = 14). White preproghrelin Met72Met subjects in HERITAGE had the lowest BMI (p = 0.020), and those in the QFS cohort had the lowest FM (p < 0.001). Met72 carrier status (Met72+) was associated with lower FM (p = 0.026) and higher insulin-like growth factor-1 levels (p = 0.019) among blacks. Met72Met QFS subjects had less visceral fat (p = 0.002) and a lower fasting respiratory quotient (p = 0.037). HERITAGE Met72+ white subjects also showed lower exercise respiratory quotient (p = 0.030) and higher maximal oxygen uptake (p = 0.023). Furthermore, the prevalence of Met72+ was higher (19.2%; p < 0.05) in SOS subjects whose BMI was < or =25 kg/m(2) than in those with BMI >25 kg/m(2) (14.8%). SOS Met72+ obese women had a lower (11.4%; p = 0.032) prevalence of hypertension than noncarriers (23.9%).

DISCUSSION
Arg51Gln mutation was associated with lower plasma ghrelin levels but not with obesity. The preproghrelin Met72 carrier status seems to be protective against fat accumulation and associated metabolic comorbidities.