Role of ghrelin polymorphisms in obesity based on three different studies.

@article{Ukkola2002RoleOG,
  title={Role of ghrelin polymorphisms in obesity based on three different studies.},
  author={Olavi H. Ukkola and Eric Ravussin and Peter Jacobson and Louis P{\'e}russe and Tuomo Rankinen and Matthias H. Tsch{\"o}p and Mark Louis Heiman and Arthur S. Leon and D. C. Rao and James S. Skinner and Jack H. Wilmore and Lars Sj{\"o}str{\"o}m and Claude Bouchard},
  journal={Obesity research},
  year={2002},
  volume={10 8},
  pages={
          782-91
        }
}
OBJECTIVE Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study. RESEARCH METHODS AND PROCEDURES Body mass index (BMI), fat mass (FM) from underwater weighing, and abdominal fat from computerized tomography were measured. The ghrelin polymorphisms were identified by polymerase chain reaction. RESULTS Arg51Gln QFS subjects… 
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Leu72Met polymorphism of GHRL gene decreases susceptibility to type 2 diabetes mellitus in a Mexican population
TLDR
The aim of this study was to investigate the association between the GHRL Leu72Met (rs696217) SNP with the development of T2D and serum ghrelin levels in a Western Mexican population and found a significant protective effect of the 72Met allele.
Dual Effect of the GHRL Gene Variant in the Molecular Pathogenesis of Obesity
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The results indicate that the GHRL Leu72Met polymorphism was found to be significantly higher in obese patients, with respect to genotypic and allelic frequencies, and may be considered as risk and crucial marker for both obesity and cholesterol metabolism in the community of Turkish-Cypriots.
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