Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation.

@article{Gupta2018RoleOG,
  title={Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation.},
  author={Dhanak Gupta and David E. Grant and Kazi M Zakir Hossain and Ifty Ahmed and Virginie Sottile},
  journal={Journal of biomaterials applications},
  year={2018},
  volume={32 7},
  pages={906-919}
}
Mesenchymal stem cells play a vital role in bone formation process by differentiating into osteoblasts, in a tissue that offers not a flat but a discontinuous three-dimensional (3D) topography in vivo. In order to understand how geometry may be affecting mesenchymal stem cells, this study explored the influence of 3D geometry on mesenchymal stem cell-fate by comparing cell growth, viability and osteogenic potential using monolayer (two-dimensional, 2D) with microsphere (3D) culture systems… CONTINUE READING