Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa.

@article{Sikka2001RoleOG,
  title={Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa.},
  author={Suresh C Sikka and Hunter C. Champion and Trinity J. Bivalacqua and Lance S Estrada and Run Ming Wang and Mahadevan Raj Rajasekaran and Bharat Bhushan Aggarwal and Wayne J. G. Hellstrom},
  journal={International journal of andrology},
  year={2001},
  volume={24 3},
  pages={136-41}
}
Pro-inflammatory cytokines are elevated in the semen of patients with genitourinary inflammation (GUI). Whether this increase in cytokines in GUI patients plays any critical role in male factor infertility is not clear. The present study investigated the in vitro effects of two important pro-inflammatory cytokines, lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma), on sperm motility, viability, membrane integrity and motion parameters. Washed spermatozoa from healthy donors were… CONTINUE READING
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