Role of genetic polymorphisms and ovarian cancer susceptibility.

  title={Role of genetic polymorphisms and ovarian cancer susceptibility.},
  author={Peter A. Fasching and Simon A. Gayther and Leigh J Pearce and Joellen Martha Schildkraut and Ellen Goode and Falk Clemens Thiel and Georgia Chenevix-Trench and Jenny Chang-Claude and Shan Wang-gohrke and Susan J Ramus and Paul D P Pharoah and Andrew Berchuck},
  journal={Molecular oncology},
  volume={3 2},
The value of identifying women with an inherited predisposition to epithelial ovarian cancer has become readily apparent with the identification of the BRCA1, and BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very high lifetime risk of ovarian cancer (10-60%) and to some extent, increased risks of fallopian tube and peritoneal cancer. These highly lethal cancers are almost completely prevented by prophylactic salpingoophorectomy. BRCA1/2 mutation testing… CONTINUE READING


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