Role of genetic polymorphisms and ovarian cancer susceptibility

  title={Role of genetic polymorphisms and ovarian cancer susceptibility},
  author={P. Fasching and S. Gayther and L. Pearce and J. Schildkraut and E. Goode and F. Thiel and G. Chenevix-Trench and J. Chang-Claude and S. Wang-Gohrke and S. Ramus and P. Pharoah and A. Berchuck},
  journal={Molecular Oncology},
  • P. Fasching, S. Gayther, +9 authors A. Berchuck
  • Published 2009
  • Medicine
  • Molecular Oncology
  • The value of identifying women with an inherited predisposition to epithelial ovarian cancer has become readily apparent with the identification of the BRCA1, and BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very high lifetime risk of ovarian cancer (10–60%) and to some extent, increased risks of fallopian tube and peritoneal cancer. These highly lethal cancers are almost completely prevented by prophylactic salpingoophorectomy. BRCA1/2 mutation testing… CONTINUE READING
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