Role of genetic polymorphisms and ovarian cancer susceptibility
@article{Fasching2009RoleOG, title={Role of genetic polymorphisms and ovarian cancer susceptibility}, author={P. Fasching and S. Gayther and L. Pearce and J. Schildkraut and E. Goode and F. Thiel and G. Chenevix-Trench and J. Chang-Claude and S. Wang-Gohrke and S. Ramus and P. Pharoah and A. Berchuck}, journal={Molecular Oncology}, year={2009}, volume={3} }
The value of identifying women with an inherited predisposition to epithelial ovarian cancer has become readily apparent with the identification of the BRCA1, and BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very high lifetime risk of ovarian cancer (10–60%) and to some extent, increased risks of fallopian tube and peritoneal cancer. These highly lethal cancers are almost completely prevented by prophylactic salpingoophorectomy. BRCA1/2 mutation testing… CONTINUE READING
Topics from this paper
76 Citations
The inherited genetics of ovarian and endometrial cancer.
- Biology, Medicine
- Current opinion in genetics & development
- 2010
- 56
Hereditary breast and ovarian cancer (HBOC): clinical features and counseling for BRCA1 and BRCA2, Lynch syndrome, Cowden syndrome, and Li-Fraumeni syndrome.
- Medicine
- Obstetrics and gynecology clinics of North America
- 2010
- 35
Role of DNA repair and cell cycle control genes in ovarian cancer susceptibility
- Biology, Medicine
- Molecular Biology Reports
- 2012
- 17
Gynaecological cancers in genetically susceptible women: new thoughts on tubal pathology
- Medicine
- 2009
- 4
Breast Cancer Risk - From Genetics to Molecular Understanding of Pathogenesis.
- Medicine
- Geburtshilfe und Frauenheilkunde
- 2013
- 37
- PDF
Genetic susceptibility to sporadic ovarian cancer: a systematic review.
- Biology, Medicine
- Biochimica et biophysica acta
- 2011
- 34
Discovery Analysis of TCGA Data Reveals Association between Germline Genotype and Survival in Ovarian Cancer Patients
- Biology, Medicine
- PloS one
- 2013
- 26
- PDF
The new face of ovarian cancer modeling: better prospects for detection and treatment
- Medicine
- F1000 medicine reports
- 2011
- 21
- PDF
References
SHOWING 1-10 OF 77 REFERENCES
No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer.
- Medicine
- Cancer letters
- 2006
- 79
DNA repair gene ERCC2 polymorphisms and associations with breast and ovarian cancer risk
- Medicine, Biology
- Molecular Cancer
- 2007
- 41
Sequence analysis of BRCA1 and BRCA2: correlation of mutations with family history and ovarian cancer risk.
- Medicine
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- 1998
- 455
A novel duplication polymorphism in the FANCA promoter and its association with breast and ovarian cancer
- Biology, Medicine
- BMC Cancer
- 2004
- 19
- PDF
Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone.
- Biology, Medicine
- Journal of the National Cancer Institute
- 1998
- 758
- PDF
RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women.
- Biology, Medicine
- Cancer letters
- 2005
- 7
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.
- Medicine
- American journal of human genetics
- 2003
- 3,146
BRCA1 sequence analysis in women at high risk for susceptibility mutations. Risk factor analysis and implications for genetic testing.
- Medicine
- JAMA
- 1997
- 390
Progesterone receptor (PROGINS) polymorphism and the risk of ovarian cancer
- Biology, Medicine
- Steroids
- 2008
- 23