• Medicine
• Published in Molecular oncology 2009
• DOI:10.1016/j.molonc.2009.01.008

Role of genetic polymorphisms and ovarian cancer susceptibility.

@article{Fasching2009RoleOG,
  title={Role of genetic polymorphisms and ovarian cancer susceptibility.},
  author={Peter A. Fasching and Simon A. Gayther and Leigh J. Pearce and Joellen M Schildkraut and Ellen L. Goode and Falk Clemens Thiel and Georgia Chenevix-Trench and Jenny Chang-Claude and Shan Wang-gohrke and Susan J Ramus and Paul D. Pharoah and Andrew Berchuck},
  journal={Molecular oncology},
  year={2009},
  volume={3 2},
  pages={
          171-81
        }
}

• Peter A. Fasching, Simon A. Gayther, +9 authors Andrew Berchuck

The value of identifying women with an inherited predisposition to epithelial ovarian cancer has become readily apparent with the identification of the BRCA1, and BRCA2 genes. Women who inherit a deleterious mutation in either of these genes have a very high lifetime risk of ovarian cancer (10-60%) and to some extent, increased risks of fallopian tube and peritoneal cancer. These highly lethal cancers are almost completely prevented by prophylactic salpingoophorectomy. BRCA1/2 mutation testing… CONTINUE READING

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