Role of genetic modifiers in an orthologous rat model of ARPKD.

Abstract

Human data and animal models of autosomal recessive polycystic kidney disease (ARPKD) suggest that genetic factors modulate the onset and severity of the disease. We report here for the first time that ARPKD susceptibility is attenuated by introgressing the mutated Pkhd1 disease allele from the polycystic kidney (PCK) rat onto the FHH (Fawn-Hooded… (More)
DOI: 10.1152/physiolgenomics.00187.2011

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