Role of genes GSTM1, GSTT1, and MnSOD in the development of late-onset Alzheimer disease and their relationship with APOE*4.

@article{Mendonca2016RoleOG,
  title={Role of genes GSTM1, GSTT1, and MnSOD in the development of late-onset Alzheimer disease and their relationship with APOE*4.},
  author={Elizabeth de Mendonca and E Salazar Alcal{\'a} and Mercedes T Fern{\'a}ndez-Mestre},
  journal={Neurologia},
  year={2016},
  volume={31 8},
  pages={535-42}
}
INTRODUCTION Several studies have reported increased oxidation of lipids, proteins and DNA in the brains of patients with Alzheimer disease (AD). Moreover, these patients display differences in the activity and polymorphisms of the genes encoding the enzymes GST (T1, M1) and MnSOD. For these reasons, we designed a study of the variability in GSTT1, GSTM1, and MnSOD genes in healthy and AD groups from a Venezuelan population. METHODS We included 179 unrelated Venezuelan subjects classified as… CONTINUE READING
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