Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats

@article{Kawakubo2005RoleOG,
  title={Role of gastric mast cells in the regulation of central TRH analog-induced hyperemia in rats},
  author={K. Kawakubo and Y. Akiba and D. Adelson and P. Guth and J. Kaunitz},
  journal={Peptides},
  year={2005},
  volume={26},
  pages={1580-1589}
}
  • K. Kawakubo, Y. Akiba, +2 authors J. Kaunitz
  • Published 2005
  • Biology, Medicine
  • Peptides
  • RX 77368 (RX) increases gastric mucosal blood flow by a vagal cholinergic mechanism. The relative roles of mucosal and connective tissue mast cells (MMC and CTMC) were investigated in RX-injected rats. Blood flow and mast cell degranulation were measured after intracisternal RX. RX significantly increased gastric mucosal blood flow, and sequentially degranulated CTMC and MMC. Ketotifen or doxantrazole inhibited the hyperemic response. Ondansetron, RS-039604-90, or famotidine, but not ketanserin… CONTINUE READING
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