Role of gangliosides in Alzheimer's disease.

@article{Yanagisawa2007RoleOG,
  title={Role of gangliosides in Alzheimer's disease.},
  author={Katsuhiko Yanagisawa},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1768 8},
  pages={
          1943-51
        }
}
One of the fundamental questions regarding the pathogenesis of Alzheimer's disease (AD) is how the monomeric, nontoxic amyloid beta-protein (Abeta) is converted to its toxic assemblies in the brain. A unique Abeta species was identified previously in an AD brain, which is characterized by its binding to the GM1 ganglioside (GM1). On the basis of the molecular characteristics of this GM1-bound Abeta (GAbeta), it was hypothesized that Abeta adopts an altered conformation through its binding to… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 58 CITATIONS

FILTER CITATIONS BY YEAR

2008
2018

CITATION STATISTICS

  • 9 Highly Influenced Citations

  • Averaged 3 Citations per year over the last 3 years

Similar Papers

Loading similar papers…