Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection.

@article{Obonyo2002RoleOG,
  title={Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection.},
  author={Marygorret Obonyo and Donald G. Guiney and Julia Harwood and Joshua A. Fierer and Sheri P. Cole},
  journal={Infection and immunity},
  year={2002},
  volume={70 6},
  pages={
          3295-9
        }
}
Gamma interferon (IFN-gamma) has been proposed to play an important role in Helicobacter-related gastritis. Using the IFN-gamma gene knockout (IFN-gamma(-/-)) mouse model and a murine gastric epithelial cell line, GSM06, we demonstrated that Helicobacter pylori maximally induced macrophage inflammatory protein-2 (MIP-2) and inducible nitric oxide synthase (iNOS) mRNA only in wild-type mice. MIP-2 and iNOS mRNA were also induced by H. pylori in GSM06 cells. Induction of cyclooxygenase 2 mRNA… CONTINUE READING

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