Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi.

@article{Babu2000RoleOG,
  title={Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi.},
  author={Subash Babu and Lisa Ganley and Thomas R. Klei and Leonard D Shultz and Thiruchandurai V. Rajan},
  journal={Infection and immunity},
  year={2000},
  volume={68 5},
  pages={3034-5}
}
We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-gamma or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection. 

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