Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication.

@article{Dragomir2012RoleOG,
  title={Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication.},
  author={Ana-Cristina Docan Dragomir and Richard Sun and Hyejeong Choi and Jeffrey D Laskin and Debra L. Laskin},
  journal={Journal of immunology},
  year={2012},
  volume={189 12},
  pages={5934-41}
}
Inflammatory macrophages have been implicated in hepatotoxicity induced by the analgesic acetaminophen (APAP). In these studies, we characterized the phenotype of macrophages accumulating in the liver following APAP intoxication and evaluated the role of galectin-3 (Gal-3) in macrophage activation. Administration of APAP (300 mg/kg, i.p.) to wild-type mice resulted in the appearance of two distinct subpopulations of CD11b(+) cells in the liver, which expressed high or low levels of the monocyte… CONTINUE READING