Role of galectin-3 in adenocarcinoma liver metastasis.

  title={Role of galectin-3 in adenocarcinoma liver metastasis.},
  author={Haruhiko Inufusa and Michio Nakamura and Tetsuya Adachi and Mini Aga and Masashi Kurimoto and Yukio Nakatani and Tsukasa Wakano and Masayuki Miyake and Kazuto Okuno and Hitoshi Shiozaki and Masayuki Yasutomi},
  journal={International journal of oncology},
  volume={19 5},
Galectin-3 is a lactosamine-specific lectin that binds to laminin sugar-sites, and up-regulated expression of galectin-3 in primary colorectal cancer is involved in cancer progression and metastasis. Inhibitory effects of cell adhesion and liver metastasis of adenocarcinoma via portal vein by lectin-binding sugar and anti-galectin-3 antibody was examined to determine the role of galectin-laminin binding in cancer liver metastasis. Highly metastatic adenocarcinoma cell lines XK4-A3 and RPMI4788… CONTINUE READING