Role of galactose in bovine factor V.

  title={Role of galactose in bovine factor V.},
  author={Saras Saraswathi and Robert W. Colman},
  journal={The Journal of biological chemistry},
  volume={250 20},
Using galactose oxidase as well as beta-galactosidase to produce modifications of the galactose units, the functional significance of these carbohydrate residues on the coagulant activity of bovine Factor V glycoprotein was evaluated. Incubation of native Factor V with galactose oxidase or hydrolysis of asialo-Factor V with beta-galactosidase results in a loss of Factor V activity. The inactivation of Factor V by oxidation of galactose moieties is partially reversible upon reduction of the… CONTINUE READING


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