Role of functional polymorphisms of P53 and P73 genes with the risk of prostate cancer in a case-control study from Northern India.

@article{Mittal2011RoleOF,
  title={Role of functional polymorphisms of P53 and P73 genes with the risk of prostate cancer in a case-control study from Northern India.},
  author={Rama Devi Mittal and Ginu P. George and Jyotsna K. Mishra and Tulika Mittal and Rakesh Kapoor},
  journal={Archives of medical research},
  year={2011},
  volume={42 2},
  pages={
          122-7
        }
}
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Evaluation of P53 Polymorphism Susceptibility in Oral Cancer in Population From Gujarat, India
TLDR
There is a significant association between all the above polymorphisms and risk of developing oral squamous cell carcinoma in Gujarat, India.
Association between p53 gene variants and oral cancer susceptibility in population from Gujarat, West India.
BACKGROUND p53 gene variants i.e. 16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies. Therefore, the present…
Prevalence of p53 codon 72, p73 G4C14-A4T14 and MDM2 T309G polymorphisms and its association with the risk of oral cancer in South Indians
A Case-Control Study on the p73 G4A Gene Polymorphism and Susceptibility to Breast Cancer in an Iranian Population
TLDR
There was no association between G4A p73 polymorphism and the risk of breast cancer in a northeastern Iranian population and the abundance of this allele between case and control groups was not statistically meaningful and, as a result, not associated with therisk of breast cancers in this study group.
No evidence of correlation between p53 codon 72 G > C gene polymorphism and cancer risk in Indian population: a meta-analysis
TLDR
The present meta-analysis indicated that the p53 codon 72 G’> C polymorphism was not associated with cancer risk, suggesting that this polymorphism may not be an independent risk factor for cancer in the Indian population.
The role of p73 G4C14-to-A4T14 polymorphism in the susceptibility to cervical cancer.
TLDR
A twofold increased susceptibility to the development of HSIL in women carrying the p73 AT allele is demonstrated, in agreement with the possible role of p73 in cervical carcinogenesis, namely, in human papillomavirus- infected transition zone subjected to the action of estrogens.
Association of p53 and p21 polymorphisms with prostate cancer.
TLDR
This is the first study to show that a combination of the variant genotypes of p53 codon 72 and p21 C98A may modify the prostate cancer risk within the Slovak population.
Association between polymorphisms in TP53 and MDM2 genes and susceptibility to prostate cancer.
TLDR
It is demonstrated that the 40-bp I/D polymorphism in the MDM2 promoter increased the risk of PCa in an Iranian population and further investigations with diverse ethnicities and larger sample sizes are required to verify these results.
Role of p73 Dinucleotide Polymorphism in Prostate Cancer and p73 Protein Isoform Balance
TLDR
Findings are consistent with an association between p73 DNP and low risk for PCa aggressiveness by increasing the expressed TAp73/∆Np73 protein isoform ratio.
The TP53 Codon 72 Polymorphism and Risk of Sporadic Prostate Cancer among Iranian Patients
TLDR
This study conducted a case-control study of 40 sporadic prostate cancer patients and 80 benign prostate hyperplasia cases to clarify if this polymorphism is associated with an increased risk of prostate cancer in Iranian men and found a significant association between the TP53 codon 72 genotype and prostate cancer risk.
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References

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A case-control study on the combined effects of p53 and p73 polymorphisms on head and neck cancer risk in an Italian population
TLDR
This study provides for the first time evidence that individuals carrying p53 exon 4 and p53 intron 6 variant alleles are significantly protected against squamous cell carcinoma of the head and neck (SCCHN), and shows that an additional risk is conferred by the combination of p73 exon 2 G4C14-to-A4T14 and p73 intron 3 variant allele.
p53 Codon 72 and p21 codon 31 polymorphisms in prostate cancer.
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  • Biology, Medicine
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TLDR
The findings suggest that the p21 codon 31 polymorphism may be associated with the development of prostate enlargement and cancer.
p53 polymorphisms and haplotypes in breast cancer.
TLDR
Three polymorphisms in the human tumor suppressor gene p53 and RFLPs in exon 4 and intron 6 respectively and a 16 bp duplication in intron 3 and their haplotype combinations were studied in patients with breast cancer and controls, indicating that the codon 72 pro allele may be functionally involved in low malignancy breast cancer.
A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA
TLDR
A role for p53PIN3 in tumorigenesis is suggested, supported by the in vitro characterization of this variant, with the same order of magnitude as that observed in previous studies for other types of cancer.
Combined Effects of the p53 and p73 Polymorphisms on Lung Cancer Risk
TLDR
Support is provided for the multigenetic effects of variant alleles from p53 exon 4, and introns 3 and 6, and p73, and their interplay with smoking, resulting in a significantly increased risk for lung cancer in this Caucasian population.
Association of p73 G4C14-to-A4T14 (GC/AT) polymorphism with breast cancer survival.
TLDR
The results suggest that the GC/GC genotype is significantly associated with poor prognosis in breast cancer and raise the possibility that analysis of p73 polymorphism may provide useful prognostic information for breast cancer patients.
Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck.
TLDR
The results suggest that this p73 polymorphism may be a risk marker for genetic susceptibility to SCCHN.
p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity.
TLDR
Genotype and haplotype frequency distributions were strongly dependent on ethnicity; variant allele frequencies were highest in African-Americans (29.1%) and lowest in Mexican-American (12.2%).
Association of the TP53 codon 72 polymorphism with colorectal cancer in a Chinese population.
TLDR
It is concluded that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers.
Chilean pilot study on the risk of lung cancer associated with codon 72 polymorphism in the gene of protein p53.
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