Role of free radicals in aseptic loosening of hip arthroplasty.

  title={Role of free radicals in aseptic loosening of hip arthroplasty.},
  author={Plamen Kinov and Andreas Leithner and Roman Radl and Koppany Bod{\'o} and Gholam-Ali Khoschsorur and Konrad Schauenstein and Reinhard Windhager},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={24 1},
Fibrous pseudocapsule around hip implants is an invariable finding at revision operations and is believed to release inflammatory mediators that stimulate bone resorption. Reactive oxygen species have been proposed to be causative factors in various disorders with tissue fibrosis. We were interested in investigating whether aseptic loosening is connected with high oxidative stress, and in showing the underlying mechanism of periprosthetic fibrosis and its role in loosening. Levels of oxidative… CONTINUE READING
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