Role of free nitrogen and oxygen radicals in the pathogenesis of lipopolysaccharide-induced endotoxemia

@article{Sanikidze2006RoleOF,
  title={Role of free nitrogen and oxygen radicals in the pathogenesis of lipopolysaccharide-induced endotoxemia},
  author={Tamar V. Sanikidze and N. G. Tkhilava and M. B. Papava and I. V. Datunashvili and M. T. Gongadze and D. D. Gamrekelashvili and V. I. Bakhutashvili},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2006},
  volume={141},
  pages={211-215}
}
We studied molecular mechanisms of changes in oxidative metabolism under conditions of experimental lipopolysaccharide-induced endotoxemia. Generation of reactive nitrogen and oxygen species in mice increased 18 h after treatment with lipopolysaccharide. These changes contributed to inactivation of enzymes and enzyme complexes (ribonucleotide reductase, NADH-ubiquinone oxidoreductase, and cytochrome c oxidase), dysfunction of the mitochondrial electron transport chain, and development of… CONTINUE READING

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2 Excerpts

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