Role of foldability and stability in designing real protein sequences.

This work explores the effects of two different fitness criteria, the free energy of folding (ΔG(folding)) and foldability (Φ) of mutated sequences, by measuring the designed protein's robustness via cumulative random point mutations. The results of a self-consistent mean-field based theory are used to design 'wild type' protein sequences corresponding to a… CONTINUE READING